Green synthesis of 2-aryl-4-phenyl-quınazolıne derıvatives promoted by lactıc acıd

Belgheis Adrom, Nourallah Hazeri, Malek Taher Maghsoodlou, Mojtaba Lashkari, Maryam Fatahpour

Abstract


An environmentally benign three-component synthetic method is described for the construction of 2-aryl-4-phenylquinazoline derivatives from the reaction between aldehydes, ammonium acetate, and 2-aminobenzophenone in the presence of lactic acid in a solvent-less media. The benefits of the reaction were good yields, a simple procedure, simple starting materials short reaction time, easy work-up, and cleaner reaction profiles.


Keywords


Green protocol; Quinazoline derivatives; Multi-component reaction; Lactic acid; Solvent-free conditions

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References


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DOI: http://dx.doi.org/10.20450/mjcce.2017.1137

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