Microwave-assisted synthesis of biologically active amide derivatives of naphthenic acids under neat conditions

Authors

  • Ljubica Grbović Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21 000 Novi Sad
  • Bojana Radovan Vasiljević Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21 000 Novi Sad
  • Ksenija Pavlović Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21 000 Novi Sad
  • Timea Hajnal-Jafari Department of Field and Vegetable Crops, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21 000 Novi Sad
  • Simonida Đurić Department of Field and Vegetable Crops, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21 000 Novi Sad
  • Mirjana Popsavin Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21 000 Novi Sad
  • Slavko Kevrešan Department of Field and Vegetable Crops, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21 000 Novi Sad

DOI:

https://doi.org/10.20450/mjcce.2018.1371

Keywords:

green chemistry, naphthenic acid amides, solvent-free synthesis, plant rooting agents, bacterial proliferation

Abstract

Within the field of green chemistry, a noticeable results were obtained in the solvent-free synthesis of amide derivatives of naphthenic acids under microwave irradiation. Naphthenic acid amides, anilides, and morpholides were synthesized directly from free carboxylic acids and amines in the absence of solvent and catalyst under high-temperature heating in a closed-vessel system of microwave reactor. With this new and efficient method, different primary, secondary, and tertiary amide derivatives of naphthenic acids were obtained in good to excellent yields. Synthesized derivatives were assayed as plant rooting agents for their stimulative effects on the formation of adventitious roots in sunflower cuttings and susceptibility for growth stimulation of Pseudomonas sp. strains.

Author Biographies

Ljubica Grbović, Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21 000 Novi Sad

Prof. dr Ljubica Grbović is professor at University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection. Organic chemistry.

Bojana Radovan Vasiljević, Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21 000 Novi Sad

Dr Bojana Vasiljević is researcher at University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection. Organic chemistry.

Ksenija Pavlović, Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21 000 Novi Sad

Dr Ksenija Pavlović is assistant professor at University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection. Organic chemistry.

Timea Hajnal-Jafari, Department of Field and Vegetable Crops, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21 000 Novi Sad

Timea Hajnal-Jafari is researcher at University of Novi Sad, Department of Field and Vegetable Crops, Faculty of Agriculture. Microbiology.

Simonida Đurić, Department of Field and Vegetable Crops, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21 000 Novi Sad

Prof. dr Simonida Đurić is professor at University of Novi Sad, Department of Field and Vegetable Crops, Faculty of Agriculture. Microbiology.

Mirjana Popsavin, Department of Chemistry, Biochemistry and Environmental Protection, Faculty of Sciences, University of Novi Sad, Trg Dositeja Obradovića 3, 21 000 Novi Sad

Prof. dr Mirjana Popsavin is professor at University of Novi Sad, Faculty of Sciences, Department of Chemistry, Biochemistry and Environmental Protection. Organic chemistry.

Slavko Kevrešan, Department of Field and Vegetable Crops, Faculty of Agriculture, University of Novi Sad, Trg Dositeja Obradovića 8, 21 000 Novi Sad

Prof.dr Slavko Kevrešan is retired professor at University of Novi Sad, Department of Field and Vegetable Crops, Faculty of Agriculture.

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Published

2018-06-09

How to Cite

Grbović, L., Vasiljević, B. R., Pavlović, K., Hajnal-Jafari, T., Đurić, S., Popsavin, M., & Kevrešan, S. (2018). Microwave-assisted synthesis of biologically active amide derivatives of naphthenic acids under neat conditions. Macedonian Journal of Chemistry and Chemical Engineering, 37(1), 13–20. https://doi.org/10.20450/mjcce.2018.1371

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Section

Organic Chemistry

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