Chiral separation by ligand-exchange

Authors

  • Martin G Schmid Institute of Pharmaceutical Sciences, Dept. of Pharmaceutical Chemistry, Karl-Franzens-University, Universitätsplatz 1, A–8010 Graz, Austria
  • Gerald Gübitz Institute of Pharmaceutical Sciences, Dept. of Pharmaceutical Chemistry, Karl-Franzens-University, Universitätsplatz 1, A–8010 Graz, Austria

DOI:

https://doi.org/10.20450/mjcce.2011.4

Keywords:

ligand-exchange, chiral selectors, chemically bonded phases, dynamically coated phases, monolithic phases, HPLC, capillary electrophoresis, capillary electrochromatography

Abstract

The principle of chiral ligand-exchange, introduced by Davankov, has become a widely used technique for chiral separation in both chromatography and in electromigration techniques. This simple technique makes use of the formation of mixed metal chelate complexes between a chiral selector and both enantiomers of an analyte. In HPLC, the chiral selector can be either bonded to the stationary phase or added to the mobile phase. In CE the chiral selector is simply added to the electrolyte. A relatively new approach represents CEC, where capillaries contain a chiral stationary phase. More than thousand papers appeared in the field of chiral ligand-exchange. To cite all papers would require several books.
The present article gives an overview of both milestones and our activities on chiral separation using the principle of ligand-exchange. Recent advances in chip technology for chiral separations and new approaches regarding improvement of detection sensitivity are mentioned.

References

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Rogozhin, S. V. and Davankov, V. A.: USSR patent 308635, (1968).

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Schmid, M. G.: unpublished results.

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Schmid, M. G. and Gübitz, G.: Direct enantiomer separation of underivatized amino acids by cap¬illary zone electrophoresis based on ligand ex¬change. Enantiomer, 1, 23–27 (1996).

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Published

2011-12-25

How to Cite

Schmid, M. G., & Gübitz, G. (2011). Chiral separation by ligand-exchange. Macedonian Journal of Chemistry and Chemical Engineering, 30(2), 127–137. https://doi.org/10.20450/mjcce.2011.4

Issue

Vol. 30 No. 2 (2011)

Section

Analytical Chemistry

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