Part XVI - Stereospecific ligands and their complexes. Synthesis, characterization and in vitro antiproliferative activity of new platinum(IV) complexes with some O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-propanoic acid against breast cancer

Authors

  • Verica V Jevtic Department of Chemistry, Faculty of Science, University of Kragujevac
  • Gordana P Radic Department of Chemistry, Faculty of Science, University of Kragujevac
  • Dragana Seklic Department of Biology and Ecology, Faculty of Science, University of Kragujevac
  • Marko Zivanovic Department of Biology and Ecology, Faculty of Science, University of Kragujevac
  • Snezana Markovic Department of Biology and Ecology, Faculty of Science, University of Kragujevac
  • Srecko R Trifunovic Department of Chemistry, Faculty of Science, University of Kragujevac

DOI:

https://doi.org/10.20450/mjcce.2014.148

Keywords:

Platinum(IV) complexes, O, O'-dialkyl esters, antiproliferative activity, MTT test,

Abstract

Synthesis of four new platinum(IV) complexes C1–C4, with bidentate N,N'-ligand precursors, O,O'-dialkyl esters L1-L4 (alkyl = ethyl, propyl, butyl and pentyl), of (S,S)-ethylenediamine-N,N'-di-2-propanoic acid, H2-S,S-eddp were reported. The reported platinum(IV) complexes characterized by elemental analysis and their structures were discussed on the bases of their infrared, 1H and 13C NMR spectroscopy. The cytotoxic activity was determined on tumor cell lines: human breast carcinoma MDA-MB-231, human colon carcinoma HCT-116 and SW-480, using MTT test. It showed the greater the size of the investigated complex or ligand the greater the cytotoxicity.

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Published

2014-04-17

How to Cite

Jevtic, V. V., Radic, G. P., Seklic, D., Zivanovic, M., Markovic, S., & Trifunovic, S. R. (2014). Part XVI - Stereospecific ligands and their complexes. Synthesis, characterization and in vitro antiproliferative activity of new platinum(IV) complexes with some O,O’-dialkyl esters of (S,S)-ethylenediamine-N,N’-di-2-propanoic acid against breast cancer. Macedonian Journal of Chemistry and Chemical Engineering, 33(1), 53–58. https://doi.org/10.20450/mjcce.2014.148

Issue

Vol. 33 No. 1 (2014)

Section

Inorganic Chemistry

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