In vitro antimalarial activity of some organotin(IV)2-nitrobenzoate compounds against Plasmodium falciparum

Authors

DOI:

https://doi.org/10.20450/mjcce.2018.1414

Keywords:

antimalaria activity, IC50, organotin(IV) nitrobenzoate, P. falcifarum

Abstract

Antimalarial activity study of organotin(IV) derivatives with nitrobenzoic acid derivatives used as ligands has been performed. The targeted compounds were prepared from their organotin(IV) chlorides via dibutyltin(IV) oxide, diphenyltin(IV) dihydroxide, and triphenyltin(IV) hydroxide intermediate products, followed by reacting the intermediate products with 2-nitrobenzoic acid. The antimalarial activity was performed against P. falciparum. The results showed that the IC50values of dibutyiltin(IV) di-2-nitrobenzoate, diphenyltin(IV) di-2-nitrobenzoate, and triphenyltin(IV) 2-nitrobenzoate were in 8.4 × 10‑3, 5.3 × 10–2, and 9.1 × 10–3 µg/ml, respectively. The IC50 values were slightly higher than the value for chloroquine (2 × 10–3 µg/ml) used as the positive control; however, one advantage is that all prepared organotin(IV) compounds were not resistant to Plasmodium, making the use of organotin(IV) as an antimalarial is possible. The results indicated that the derivative of triphenyltin(IV) was more potent when used as an antimalarial, as expected, and has potential to be developed as an antimalarial drug in the future.

Author Biographies

Sutopo Hadi, University of Lampung

Professor of Chemistry

Noviany Noviany, Universitas Lampung

Associate Professor of Organic Chemistry

Mita Rilyanti, Universitas Lampung

Associate Professor of Inorganic Chemistry

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Published

2018-11-07

How to Cite

Hadi, S., Noviany, N., & Rilyanti, M. (2018). In vitro antimalarial activity of some organotin(IV)2-nitrobenzoate compounds against Plasmodium falciparum. Macedonian Journal of Chemistry and Chemical Engineering, 37(2), 185–191. https://doi.org/10.20450/mjcce.2018.1414

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Section

Inorganic Chemistry