Synthesis of New Pt(II) Complex Bearing Organoselenium Ligands and Evaluation of Cytotoxic Activity of Some Structurally Related Pd(II) Complexes

Authors

  • Ninko Radenković University of Kragujevac, Faculty of Science, Department of Chemistry
  • Marina Kostić University of Kragujevac, Institute for Information Technologies, Department of Science
  • Nataša Đorđević State University of Novi Pazar, Department of Biomedical Science, Vuka Karadzica bb, 36300 Novi Pazar
  • Zana Doličanin State University of Novi Pazar, Department of Biomedical Science, Vuka Karadzica bb, 36300 Novi Pazar
  • Tanja Soldatović State University of Novi Pazar, Department of Biomedical Science, Vuka Karadzica bb, 36300 Novi Pazar
  • Marko Živanović University of Kragujevac, Institute for Information Technologies, Department of Science
  • Vera M Divac University of Kragujevac, Faculty of Science, Department of Chemistry

DOI:

https://doi.org/10.20450/mjcce.2020.1905

Keywords:

Organoselenium chemistry, Palladium, Platinum, Cytotoxic activity, Colon carcinoma

Abstract

Herein we report the synthesis of new trans-bis(2-phenylselenylmethyl)oxolane)dichloroplatinum(II) complex Pt1. Newly synthetized complex, together with two, structurally related trans-Pd(II) complexes (trans-bis(2-(phenylselenylmethyl)oxolane)dichloropalladium(II) Pd1 and trans-bis(2-(phenylselenylmethyl)oxane)dichloropalladium(II)) Pd2, were screened for cytotoxic activity through in vitro study on the HCT-116 colorectal carcinoma cell line and on the MRC-5 healthy lung pleura cell line. Activity of complexes was assessed by comparing it to the cisplatin. The cells viability and proliferation were determined using MTT assay.

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Published

2020-05-28

How to Cite

Radenković, N., Kostić, M., Đorđević, N., Doličanin, Z., Soldatović, T., Živanović, M., & Divac, V. M. (2020). Synthesis of New Pt(II) Complex Bearing Organoselenium Ligands and Evaluation of Cytotoxic Activity of Some Structurally Related Pd(II) Complexes. Macedonian Journal of Chemistry and Chemical Engineering, 39(1), 59–64. https://doi.org/10.20450/mjcce.2020.1905

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Section

Inorganic Chemistry