Synthesis of novel 2-amino-5-arylazothiazol derivatives and their biological impacts: Assessment of toxicity and antioxidant enzymes activities

Authors

  • Mohamed Ezzat Khalifa Taif University
  • Mahmoud Abdel-Halim Mohamed Taif University
  • Noura Homoud Alshehri King Khaled-Bisha University

DOI:

https://doi.org/10.20450/mjcce.2015.689

Keywords:

2-Aminothiazole, Chalcone, Imine, Pyrazole, Azo coupling, Biological activities.

Abstract

The reactivity study of both the amino group and the aryl substituent of the newly synthesized 2-amino-5-(4-acetylphenylazo)-thiazole compound and its derivatives via various electrophilic reagents were performed to obtain the expected new bioactive chalcone, imine and pyrazole- thiazolidine derivatives. The synthesized compounds were chemically elucidated by analytical and spectral methods, and biologically evaluated upon screening in vitro and in vivo for their toxicity and antioxidant activity based on liver function enzymes.

Author Biographies

Mohamed Ezzat Khalifa, Taif University

chemistry Departmnt, PhD, Asst. prof.

 

Mahmoud Abdel-Halim Mohamed, Taif University

chemistry Departmnt, PhD, Prof.

Noura Homoud Alshehri, King Khaled-Bisha University

Chemistry department, Lecturer

References

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Published

2015-11-12

How to Cite

Khalifa, M. E., Mohamed, M. A.-H., & Alshehri, N. H. (2015). Synthesis of novel 2-amino-5-arylazothiazol derivatives and their biological impacts: Assessment of toxicity and antioxidant enzymes activities. Macedonian Journal of Chemistry and Chemical Engineering, 34(2), 309–319. https://doi.org/10.20450/mjcce.2015.689

Issue

Section

Organic Chemistry