TY - JOUR AU - Odžaković, Božana AU - Sailović, Pero AU - Bodroža, Darko AU - Kojić, Vesna AU - Jakimov, Dimitar AU - Kukrić, Zoran PY - 2021/12/08 Y2 - 2024/03/28 TI - Bioactive components and antioxidant, antiproliferative, and antihyperglycemic activities of wild cornelian cherry (Cornus mas l.) JF - Macedonian Journal of Chemistry and Chemical Engineering JA - Maced. J. Chem. Chem. Eng. VL - 40 IS - 2 SE - Food Chemistry DO - 10.20450/mjcce.2021.2417 UR - https://mjcce.org.mk/index.php/MJCCE/article/view/2417 SP - 221-230 AB - <p>The contents of polyphenolic components (total polyphenols, flavonoids, and monomeric anthocyanins) and vitamin C, and the bioactive potential (antioxidant, antiproliferative, and antihyperglycemic activities) of wild cornelian cherry were determined. Samples were collected from four different locations in Bosnia and Herzegovina. Sample CC<sub>3 </sub>from Drinić had the highest monomeric anthocyanin content (1.40 mg CyGE/g FW) and the highest inhibition of free radicals (IC<sub>50</sub><sup>DPPH</sup> = 262.19 mg/ml; IC<sub>50</sub><sup>ABTS</sup> = 76.78 mg/ml; IC<sub>50</sub><sup>OH<strong>˙</strong></sup> = 102.31 mg/ml) and inhibition of breast adenocarcinoma cell line growth (IC<sub>50</sub><sup>MCF-7</sup> = 1.37 mg/ml). Sample CC<sub>4 </sub>from Drvar showed the highest total polyphenol (55.92 mg GAE/g DW) and vitamin C (88.74 mg/g FW) contents. Sample CC<sub>4 </sub>significantly inhibited the growth of cervix epithelioid carcinoma (IC<sub>50</sub><sup>HeLa</sup> = 0.62 mg/ml) and lung adenocarcinoma (IC<sub>50</sub><sup>A549</sup> = 0.48 mg/ml) cell lines, and α-glucosidase (IC<sub>50</sub><sup>AGHA</sup> = 0.466 mg/ml). Wild cornelian cherry could be used as a functional food with beneficial pro-health properties.</p> ER -