Green synthesis of 2-aryl-4-phenyl-quınazolıne derıvatives promoted by lactıc acıd

Authors

  • Belgheis Adrom Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
  • Nourallah Hazeri Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
  • Malek Taher Maghsoodlou Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
  • Mojtaba Lashkari Faculty of Science and Engineering, Velayat University, Iranshahr, Iran
  • Maryam Fatahpour Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

DOI:

https://doi.org/10.20450/mjcce.2017.1137

Keywords:

Green protocol, Quinazoline derivatives, Multi-component reaction, Lactic acid, Solvent-free conditions

Abstract

An environmentally benign three-component synthetic method is described for the construction of 2-aryl-4-phenylquinazoline derivatives from the reaction between aldehydes, ammonium acetate, and 2-aminobenzophenone in the presence of lactic acid in a solvent-less media. The benefits of the reaction were good yields, a simple procedure, simple starting materials short reaction time, easy work-up, and cleaner reaction profiles.

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Published

2017-12-05

How to Cite

Adrom, B., Hazeri, N., Maghsoodlou, M. T., Lashkari, M., & Fatahpour, M. (2017). Green synthesis of 2-aryl-4-phenyl-quınazolıne derıvatives promoted by lactıc acıd. Macedonian Journal of Chemistry and Chemical Engineering, 36(2), 223–228. https://doi.org/10.20450/mjcce.2017.1137

Issue

Vol. 36 No. 2 (2017)

Section

Organic Chemistry

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