Isolation of Artonin E from the root bark of Artocarpus rigida, synthesis of Artonin E acetate and evaluation of anticancer activity

Authors

DOI:

https://doi.org/10.20450/mjcce.2018.1406

Keywords:

A. rigida, artonin E acetate, esterification, anticancer activity

Abstract

Artonin E was isolated from the root bark of A. rigida. The isolated compound was then esterified using a known procedure by the addition of acetic anhydride with pyridine catalyst. The structure of the synthesized compound was carefully determined by physical and spectroscopic techniques and compared to the data in the literature. The anticancer activity test against murine leukemia cancer cells P-388 showed that the ester compound has good activity with an IC50 of 2.79 μg/mL and much better stability during storage compared to Artonin E itself.

Author Biography

Sutopo Hadi, University of Lampung

Professor of Chemistry

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Published

2018-06-01

How to Cite

Suhartati, T., Hernawan, H., Suwandi, J. F., Yandri, Y., & Hadi, S. (2018). Isolation of Artonin E from the root bark of Artocarpus rigida, synthesis of Artonin E acetate and evaluation of anticancer activity. Macedonian Journal of Chemistry and Chemical Engineering, 37(1), 35–42. https://doi.org/10.20450/mjcce.2018.1406

Issue

Vol. 37 No. 1 (2018)

Section

Natural Products

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