Synthesis, characterization and biological study of new dinuclear zinc(II) and nickel(II) octaaza macrocyclic complexes


  • Milena Krstic Faculty of Veterinary Medicine, University of Belgrade, Bulevar Oslobodjenja 18 Belgrade
  • Branka Petković Department of Chemistry, Faculty of Natural Sciences and Mathematics, University of Priština, Lole Ribara 29, Kosovska Mitrovica
  • Miloš Milčić Center for Computational Chemistry and Bioinformatics, Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, Belgrade
  • Dušan Mišić Faculty of Veterinary Medicine, University of Belgrade, Bulevar oslobođenja 18, Belgrade
  • Juan Francisco Santibanez Institute for Medical Research, P.O. Box 102, Belgrade, Serbia ************************ Centro Integrativo de Biología y Química Aplicada (CIBQA), Universidad Bernardo O’Higgins, General Gana 1780, Santiago



zinc, nickel, tpmc, complex, biological activity


Two new nitrato complexes of zinc and nickel with 1,4,8,11-tetrakis(2-pyridylmethyl)-1,4,8,11-tetraazacyclotetradecane (tpmc), have been synthesized and characterized. The IR spectral peaks showed that the coordinated and ionic nitrate ions are in agreement with the formula proposed by elemental analysis. Conductometric titrations predicted methanol to be a convenient solvent for synthesis and revealed the stoichiometry of the complexes, while molar electrical conductivities indicated a 1 : 3 complex electrolyte type for the zinc complex, and a 1 : 2 complex electrolyte type for the nickel complex. The optimized complex structure was obtained by molecular modeling and density functional theory calculations. The biological activity of the novel complexes was examined by screening eight different bacterial strains and two cancer cell lines. The zinc complex showed better antimicrobial activity against the bacterial strains, while the complexes did not show significance antiproliferative activity toward cancer cells MCF-7 and MDA-MB-231.


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How to Cite

Krstic, M., Petković, B., Milčić, M., Mišić, D., & Santibanez, J. F. (2019). Synthesis, characterization and biological study of new dinuclear zinc(II) and nickel(II) octaaza macrocyclic complexes. Macedonian Journal of Chemistry and Chemical Engineering, 38(1), 1–11.



Inorganic Chemistry