Synthesis, characterization, and biological activity of 1,3-disubstitued benzimidazolium salt and its Ag-NHC complex


  • Öznur Doğan Ulu Inönü University



N-heterocyclic carbene, Benzimidazole, silver complexes, 1,3-dioxane, Antioxidant and anticancer activity


In this study, a 1,3-dioxane functionalized benzimidazole salt and its Ag-complex were synthe-sized. The prepared compounds were structurally verified by several spectroscopic techniques including 1H NMR, 13C NMR, FT-IR, LC-MS, and C, H, N analysis. Compounds were evaluated for their in vitro antioxidant activity. The salts and their Ag-NHC complexes were further evaluated for their in vitro anti-cancer activities against HCT-116 human colon cancer cells. The results showed that complex 2 exhibited high activity (4.1 times) against the cancer cell lines studied when compared to the reference drug cispla-tin. Stability studies demonstrated that these compounds are stable in aqueous and organic solutions.


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Additional Files


2023-04-28 — Updated on 2023-07-01


How to Cite

Doğan Ulu, Öznur. (2023). Synthesis, characterization, and biological activity of 1,3-disubstitued benzimidazolium salt and its Ag-NHC complex. Macedonian Journal of Chemistry and Chemical Engineering, 42(1), 67–77. (Original work published April 28, 2023)



Inorganic Chemistry