Voltammetric behavior and determination of the bronchodilator doxofylline at a boron-doped diamond electrode

Authors

  • Sachin Saxena Dayalbagh Educational Institute Dayalbagh Agra-282110
  • Ratnanjali Shrivastava Dayalbagh Educational Institute Dayalbagh Agra-282110
  • Soami P. Satsangee Dayalbagh Educational Institute Dayalbagh Agra-282110

DOI:

https://doi.org/10.20450/mjcce.2012.42

Keywords:

Doxofylline, BDDE, Voltammetry, pharmaceutical formulation.

Abstract

The electrochemical behavior of the asthma drug doxofylline was studied at a boron-doped diamond electrode in BR buffer (pH 3.8) by square-wave voltammetry. Cyclic voltammetry revealed the oxidation of doxofylline as an irreversible diffusion-controlled process. The oxidation mechanism was proposed and the drug was studied in the presence of solubilized systems like Tween-20 (T-20), sodium dodecyl sulfate (SDS), Triton X-100 (TTN), dioxane (DO), dimethylformamide (DMF), diethyl ether (DEE), benzene and methanol (MeOH). Comparison of the current responses in the solution system explained the sensitivity of the boron-doped diamond electrode (BDDE) with a three-fold increase in the current value compared to that of a glassy carbon electrode (GCE) at a fixed concentration of doxofylline. Peak current values varied linearly with increasing concentration and the LOD and LOQ were found to be 3.48 and 10.56 µg/ml, respectively. This method was employed to investigate doxofylline in the pharmaceutical formulation.

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Published

2012-12-20

How to Cite

Saxena, S., Shrivastava, R., & Satsangee, S. P. (2012). Voltammetric behavior and determination of the bronchodilator doxofylline at a boron-doped diamond electrode. Macedonian Journal of Chemistry and Chemical Engineering, 31(2), 195–203. https://doi.org/10.20450/mjcce.2012.42

Issue

Vol. 31 No. 2 (2012)

Section

Electrochemistry

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