Crystal structure of the cobalt human insulin derivative

Authors

  • Biserka Prugovečki Department of Chemistry, Division of General and Inorganic Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb
  • Natalija Ivetić Department of Chemistry, Division of General and Inorganic Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb
  • Dubravka Matković-Čalogović Department of Chemistry, Division of General and Inorganic Chemistry, Faculty of Science, University of Zagreb, Horvatovac 102a, 10000 Zagreb

DOI:

https://doi.org/10.20450/mjcce.2015.653

Keywords:

insulin derivative, cobalt, X-ray structure

Abstract

The structure of the human cobalt insulin derivative at 1.73 Å resolution is described. Single were prepared by the hanging drop vapour diffusion crystallisation method using Zn-free insulin and cobalt(II) acetate.

The crystal structure was determined by the single crystal X-ray diffraction method. The investigated insulin derivative exhibits the T6 form of insulin and crystallizes in the trigonal system in space group R3, with the unit cell parameters a = b = 81.43 Å and c = 33.75 Å. The two cobalt atoms per insulin hexamer and are octahedrally coordinated by three symmetry-related Nε2 atoms of three HisB10/HisD10 and three oxygen atoms from three water molecules.

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Published

2015-05-22

How to Cite

Prugovečki, B., Ivetić, N., & Matković-Čalogović, D. (2015). Crystal structure of the cobalt human insulin derivative. Macedonian Journal of Chemistry and Chemical Engineering, 34(1), 67–72. https://doi.org/10.20450/mjcce.2015.653

Issue

Vol. 34 No. 1 (2015)

Section

Structural Chemistry

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