Characterization of Co(II)-PAMAM dendrimer complexes with polypropylene oxide core by using UV-VIS spectroscopy

Authors

  • Ali Serol Ertürk Adıyaman University
  • Mustafa Ulvi Gürbüz Yıldız Technical University
  • Metin Tülü Yıldız Technical University
  • Abdürrezzak Emin Bozdoğan Yıldız Technical University

DOI:

https://doi.org/10.20450/mjcce.2016.895

Keywords:

PAMAM dendrimer, Jeffamine, complexation, UV-VIS spectroscopy, MRI contrast agents

Abstract

The aim of this study was to characterize poly(amidoamine) (PAMAM) dendrimer complexes of Co(II) ions by using UV-Vis spectroscopy. For this aim, a generation-4 polypropylene oxide (Jeffamine® T-403) cored and amine-terminated PAMAM dendrimer (P4) was used as a model complexation agent. Optimum complexation condition for P4 was determined by potentiometric and spectroscopic titration studies. Extent of protonation (EOP) of the amino groups of P4 was determined from the potentiometric titration data and validated with spectroscopic titration data. The results indicated that pH 8 was the optimum dendrimer aqueous solution media, where the available number of tertiary amines present in P4 was the highest for possible metal complexation. At the optimized conditions, UV-Vis characterization of the Co(II)-P4 complexes was performed and 585–635 nm d-d transition bands were observed as the characteristic complexation bands of the tertiary amine groups of P4 with Co(II) ions. Obtained Co(II)-P4 complexes might be considered for the development of magnetic resonance image (MRI) improvers or MRI contrast agents.


References

J. H. Kim, H. J. Gibb, P. D. Howe, M. Sheffer, U. N. E. Programme, I. L. Organisation, W. H. Organization, I.-O.P.f.t.S.M.o. Chemicals, Cobalt and Inorganic Cobalt Compounds, World Health Organization (2006).

S. E. Bailey, T. J. Olin, R. M. Bricka, D. D. Adrian, A review of potentially low-cost sorbents for heavy metals, Water Res., 33, 2469–2479 (1999).

DOI: 10.1016/s0043-1354(98)00475-8.

A. Kabata-Pendias, Trace Elements in Soils and Plants, Third Edition, Taylor & Francis, (2010).

DOI: 10.1201/9781420039900.ch5.

J. G. Hengstler, U. Bolm-Audorff, A. Faldum, K. Janssen, M. Reifenrath, W. Götte, D. Jung, O. Mayer-Popken, J. Fuchs, S. Gebhard, H. G. Bienfait, K. Schlink, C. Dietrich, D. Faust, B. Epe, F. Oesch, Occupational exposure to heavy metals: DNA damage induction and DNA repair inhibition prove co-exposures to cadmium, cobalt and lead as more dangerous than hitherto expected, Carcinogenesis, 24, 63–73 (2003). DOI: 10.1093/carcin/24.1.63.

K. Yamamoto, S. Inoue, A. Yamazaki, T. Yoshinaga, S. Kawanishi, Site-specific DNA damage induced by cobalt(II) ion and hydrogen peroxide: role of singlet oxygen, Chem. Res. Toxicol., 2, 234–239 (1989).

DOI: 10.1021/tx00010a004.

A. Sigel, H. Sigel, R. K. O. Sigel, Organometallics in Environment and Toxicology, RSC Publishing, (2010). DOI: 10.1039/9781849730822..

J. F. Hainfeld, Extended organic cobalt and nickel magnetic complexes, in, Google Patents (2003).

F. Zeng, S. C. Zimmerman, Dendrimers in supra-molecular chemistry: From molecular recognition to self-assembly, Chem. Rev. (Washington, D. C.), 97, 1681–1712 (1997). DOI: 10.1021/CR9603892.

M. S. Diallo, S. Christie, P. Swaminathan, L. Balogh, X. Shi, W. Um, C. Papelis, W. A. Goddard, III, J. H. Johnson, Jr., Dendritic Chelating Agents. 1. Cu(II) Binding to Ethylene Diamine Core Poly(amidoamine) Dendrimers in Aqueous Solutions, Langmuir, 20, 2640–2651 (2004).

DOI: 10.1021/la036108k.

A. D. Schluter, J. P. Rabe, Dendronized polymers: synthesis, characterization, assembly at interfaces, and manipulation, Angew. Chem., Int. Ed., 39, 864–883 (2000). DOI: 10.1002/(SICI)1521-3773(20000303)39:5<864:: AID-ANIE864>3.0.CO;2-E.

A. S. Ertürk, M. Tülü, A. E. Bozdoğan, T. Parali, Microwave assisted synthesis of Jeffamine cored PAMAM dendrimers, Eur. Polym. J., 52, 218–226 (2014). DOI: 10.1016/j.eurpolymj.2013.12.018.

A. S. Erturk, M. U. Gurbuz, M. Tulu, A. E. Bozdogan, Water-soluble TRIS-terminated PAMAM dendrimers: microwave-assisted synthesis, characterization and Cu(ii) intradendrimer complexes, RSC Adv., 5, 60581–60595 (2015). DOI: 10.1039/C5RA11157A.

I. J. Majoros, B. Keszler, S. Woehler, T. Bull, J. R. Baker, Acetylation of Poly(amidoamine) Dendrimers, Macromolecules, 36, 5526–5529 (2003).

DOI: 10.1021/ma021540e.

I. J. Majoros, T. P. Thomas, C. B. Mehta, J. R. Baker, Poly(amidoamine) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy, J. Med. Chem., 48, 5892–5899 (2005). DOI: 10.1021/jm0401863.

D. Cakara, J. Kleimann, M. Borkovec, Microscopic Protonation Equilibria of Poly(amidoamine) Dendrimers from Macroscopic Titrations, Macromolecules, 36, 4201–4207 (2003). DOI: 10.1021/ma0300241.

Y. Niu, L. Sun, R. M. Crooks, Determination of the Intrinsic Proton Binding Constants for Poly (amidoamine) Dendrimers via Potentiometric pH Titration, Macromolecules, 36, 5725–5731 (2003).

DOI: 10.1021/ma034276d.

V. Kabanov, A. Zezin, V. Rogacheva, Z. G. Gulyaeva, M. Zansochova, J. Joosten, J. Brackman, Polyelectrolyte behavior of astramol poly(propyleneimine) dendrimers, Macromolecules, 31, 5142–5144 (1998).

DOI: 10.1021/ma971643a.

L. Sun, R. M. Crooks, Interactions between Dendrimers and Charged Probe Molecules. 1. Theoretical Methods for Simulating Proton and Metal Ion Binding to Symmetric Polydentate Ligands, J. Phys. Chem. B, 106, 5864–5872 (2002). DOI: 10.1021/jp020189w.

M. H. Kleinman, J. H. Flory, D. A. Tomalia, N. J. Turro, Effect of Protonation and PAMAM Dendrimer Size on the Complexation and Dynamic Mobility of 2-Naphthol, J. Phys. Chem. B, 104, 11472–11479 (2000).

DOI: 10.1021/jp001882r.

S. Pande, R. M. Crooks, Analysis of poly(amidoamine) dendrimer structure by UV–Vis spectroscopy, Langmuir, 27, 9609–9613 (2011).

DOI: 10.1021/la201882t.

F. A. Cotton, Advanced Inorganic Chemistry, Wiley, (1999). DOI: 10.5860/choice.37-0940.

Downloads

Published

2016-10-11

How to Cite

Ertürk, A. S., Gürbüz, M. U., Tülü, M., & Bozdoğan, A. E. (2016). Characterization of Co(II)-PAMAM dendrimer complexes with polypropylene oxide core by using UV-VIS spectroscopy. Macedonian Journal of Chemistry and Chemical Engineering, 35(2), 263–270. https://doi.org/10.20450/mjcce.2016.895

Issue

Vol. 35 No. 2 (2016)

Section

Polymers

License

The authors agree to the following licence: Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)

  • Adapt — remix, transform, and build upon the material
  • for any purpose, even commercially.
The licensor cannot revoke these freedoms as long as you follow the license terms.

 Under the following terms:

  • Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

  • NonCommercial — You may not use the material for commercial purposes.