Synthesis of New Organoselenium Compounds: Characterization and Biological Studies

Authors

  • Nimra Naz Organometallic & Coordination Chemistry Laboratory, Department of Chemistry, University of Agriculture Faisalabad
  • Saima Saqib Government Postgraduate College for Women, Samanabad-Lahore, Pakistan
  • Rizwan Ashraf Department of Chemistry, University of Agriculture Faisalabad, Pakistan
  • Muhammad Irfan Majeed Department of Chemistry, University of Agriculture Faisalabad-38040, Pakistan
  • Muhammad Adnan Iqbal Organometallic & Coordination Chemistry Laboratory, Department of Chemistry, University of Agriculture Faisalabad

DOI:

https://doi.org/10.20450/mjcce.2020.1912

Keywords:

Selenium, N-Heterocyclic Carbenes, Biological

Abstract

Two new organoselenium analogs, (3,3'-(1,2-phenylenebis(methylene))bis(2-selenoxo-2,3-dihydro-1H-imidazole-3,1-diyl))bis(methylene) dibenzoate (III) and 3,3'-(1,2-phenylenebis(methylene))bis(1-benzyl-1H-imidazole-2(3H)-selenone) (V), were derived from newly synthesized organic salts 1,1'-(1,2-phenylenebis(methylene))bis(3-(2-phenoxyacetyl)-1H-imidazol-3-ium) chloride (II) and 1,1'-(1,2-phenylenebis(methylene))bis(3-benzyl-1H-imidazol-3-ium) chloride (IV), and each was characterized by various analytical techniques, such as Fourier-Transform Infrared Spectroscopy (FT-IR), UV–visible, and Nuclear Magnetic Resonance (NMR) spectroscopy, as well as Ultra-high performance liquid chromatography mass spectrometry/Photodiode array (UHPL-MS/PDA). All synthesized compounds were tested for their antioxidant and anticancer potential. Very good radical scavenging results were obtained for salts II and IV, with cell viability values of 84.6±3.5 and 56.7±5.5%, respectively, compared to their organoselenium adducts. All synthesized products showed significant activity against MCF-7 breast cancer cells, but compounds II and III showed better results, with cell viability values of 40.5±2.0% and 34.4±1.5%, respectively.

Author Biographies

Nimra Naz, Organometallic & Coordination Chemistry Laboratory, Department of Chemistry, University of Agriculture Faisalabad

MPhil Student

Saima Saqib, Government Postgraduate College for Women, Samanabad-Lahore, Pakistan

Miss Saima Saqib is Lecturer at Government Postgraduate College Lahore

Rizwan Ashraf, Department of Chemistry, University of Agriculture Faisalabad, Pakistan

Mr. Rizwan has submitted his PhD thesis for evaluation.

Muhammad Irfan Majeed, Department of Chemistry, University of Agriculture Faisalabad-38040, Pakistan

Dr. M. Irfan Majeed is Assistant Professor at UAF

Muhammad Adnan Iqbal, Organometallic & Coordination Chemistry Laboratory, Department of Chemistry, University of Agriculture Faisalabad

Dr. Iqbal was born in Punjab-Pakistan in April 1984. He completed his schooling and college education at city Faisalabad-Pakistan and bachelor degree in chemistry at university of the Punjab-Lahore-Pakistan in August 2007. He completed his masters (M.phil) in environmental sciences at college of earth and environmental science, University of the Punjab, Lahore  in 2010 and in parallel served as Lecturer of chemistry at Minhaj University Lahore till July 2010. He then joined Universiti Sains Malaysia, Penang-Malaysia in July 2010 for MS leading to PhD study in Dr. Rosenani A. Haque’s laboratory on a fellowship. He completed his PhD in organometallic chemistry in April 2014 and got an opportunity of postdoctoral fellowship at the same research laboratory. During his Ph.D studies Dr. Iqbal visited University of Western Australia, Perth, Australia on a research attachment at Professor Murray Baker’s research Laboratory. He finally joined University of Agriculture Faisalabad in September 2015 as assistant professor. Currently, he has established an organometallic and coordination chemistry laboratory at UAF community college, Faisalabad-Pakistan. His research interests include synthesis of metallodrugs. Dr. Iqbal has published more than 70 research and review articles in international journals, a book on organometallic chemistry and three book chapters. He is managing editor of two reputable research journals, Science International and Angiotherapy. He has organized several workshops, Seminars and duties as coordinator for postgraduate classes in chemistry at PARS campus for two years and also acted as convener to the coordinators at PARS.

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Se-NHC Selenones

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Published

2020-05-30

How to Cite

Naz, N., Saqib, S., Ashraf, R., Majeed, M. I., & Iqbal, M. A. (2020). Synthesis of New Organoselenium Compounds: Characterization and Biological Studies. Macedonian Journal of Chemistry and Chemical Engineering, 39(1), 1–10. https://doi.org/10.20450/mjcce.2020.1912

Issue

Vol. 39 No. 1 (2020)

Section

Organic Chemistry