Bioactive components and antioxidant, antiproliferative, and antihyperglycemic activities of wild cornelian cherry (Cornus mas l.)

Authors

  • Božana Odžaković Faculty of Technology, University of Banja Luka
  • Pero Sailović Faculty of Technology, University of Banja Luka
  • Darko Bodroža Faculty of Technology, University of Banja Luka
  • Vesna Kojić Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad
  • Dimitar Jakimov Oncology Institute of Vojvodina, Faculty of Medicine, University of Novi Sad
  • Zoran Kukrić Faculty of Technology, University of Banja Luka

DOI:

https://doi.org/10.20450/mjcce.2021.2417

Keywords:

cornelian cherry, polyphenolic compound, vitamin C, bioactivity

Abstract

The contents of polyphenolic components (total polyphenols, flavonoids, and monomeric anthocyanins) and vitamin C, and the bioactive potential (antioxidant, antiproliferative, and antihyperglycemic activities) of wild cornelian cherry were determined. Samples were collected from four different locations in Bosnia and Herzegovina. Sample CC3 from Drinić had the highest monomeric anthocyanin content (1.40 mg CyGE/g FW) and the highest inhibition of free radicals (IC50DPPH = 262.19 mg/ml; IC50ABTS = 76.78 mg/ml; IC50OH˙ = 102.31 mg/ml) and inhibition of breast adenocarcinoma cell line growth (IC50MCF-7 = 1.37 mg/ml). Sample CC4 from Drvar showed the highest total polyphenol (55.92 mg GAE/g DW) and vitamin C (88.74 mg/g FW) contents. Sample CC4 significantly inhibited the growth of cervix epithelioid carcinoma (IC50HeLa = 0.62 mg/ml) and lung adenocarcinoma (IC50A549 = 0.48 mg/ml) cell lines, and α-glucosidase (IC50AGHA = 0.466 mg/ml). Wild cornelian cherry could be used as a functional food with beneficial pro-health properties.

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Published

2021-12-08

How to Cite

Odžaković, B., Sailović, P., Bodroža, D., Kojić, V., Jakimov, D., & Kukrić, Z. (2021). Bioactive components and antioxidant, antiproliferative, and antihyperglycemic activities of wild cornelian cherry (Cornus mas l.). Macedonian Journal of Chemistry and Chemical Engineering, 40(2), 221–230. https://doi.org/10.20450/mjcce.2021.2417

Issue

Vol. 40 No. 2 (2021)

Section

Food Chemistry

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