Quantitative structure activity relationships of some N1-aryl/heteroarylaminomethyl/ethyl-1,2,4-triazoles


  • Vesna Dimova Faculty of Technology and Metallurgy, Ss Cyril and Methodius University, P. O. Box 580, MK-1001 Skopje,
  • Katica Čolančevska-Ragenoviќ Faculty of Technology and Metallurgy, Ss Cyril and Methodius University, P. O. Box 580, MK-1001 Skopje,
  • Vladimir Kukurinov Faculty of Agriculture, Department of Microbiology, Ss Cyril and Methodius University, Bul. Aleksandar Makedonski bb, Skopje,




QSAR/QSPR, N1-heteroarylaminomethyl/ethyl-1, 2, 4-triazole, physico-chemical parameters


Quantitative structure activity relationships (QSAR) analysis of a series of previously synthesized N1- arylaminomethyl/ethyl-1,2,4-triazole and N1-heteroarylaminomethyl/ethyl-1,2,4-triazole derivatives tested for growth inhibitory activity against Salmonella enteritidis, was performed using the computer-assisted multiple regression procedure. Using the Hansch and Free Wilson approaches, the activity contribution for either the aminomethyl/aminoethyl unit and aromatic/heteroaromatic ring was determined from the correlation equation. An excellent parabolic correlation was obtained between log1/C and F (regression coefficient R is 0.9800). In a bivariate correlation analysis, the correlations involving σ, MR and F were found to be good (R = 0.90 – 0.99). An excellent correlation was also obtained in tervariate correlation involving the same parameters (R = 0.995 – 0.999), with standard deviations below 0.06.



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How to Cite

Dimova, V., Čolančevska-Ragenoviќ K., & Kukurinov, V. (2006). Quantitative structure activity relationships of some N1-aryl/heteroarylaminomethyl/ethyl-1,2,4-triazoles. Macedonian Journal of Chemistry and Chemical Engineering, 25(1), 1–7. https://doi.org/10.20450/mjcce.2006.271



Organic Chemistry