Inquiry-based learning in stereochemistry: Strengthening 3D visualization and conceptual understanding

Authors

  • Aleksandra Naumoska Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Arhimedova 5, 1000 Skopje, North Macedonia https://orcid.org/0000-0002-8225-0825
  • Jane Bogdanov Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Arhimedova 5, 1000 Skopje, North Macedonia https://orcid.org/0000-0003-1187-366X
  • Slobotka Aleksovska Institute of Chemistry, Faculty of Natural Sciences and Mathematics, Ss. Cyril and Methodius University, Arhimedova 5, 1000 Skopje, North Macedonia https://orcid.org/0000-0003-4593-1194

DOI:

https://doi.org/10.20450/mjcce.2026.3443

Keywords:

stereochemistry, three-dimensional visualization, inquiry-based learning, cooperative learning, conceptual understanding

Abstract

This study examined the impact of cooperative inquiry‑based learning (IBL) using hands‑on molecular models on the learning of organic stereochemistry in a high school setting. In this approach, teacher support is minimal, allowing students to independently construct new concepts while reviewing previously acquired knowledge. The research was conducted with two parallel groups: an experimental group, which participated in the IBL interactive activities, and a control group, which followed a traditional instructional approach. The experimental group engaged in a three‑phase learning cycle of exploration, concept formation, and application. Activities were conducted through cooperative small‑group work, encouraging students to discuss ideas and compare molecular structures. Students constructed and analyzed 3D models of organic stereoisomers, applying their observations to formulate rules for different types of stereoisomerism and to visualize molecular structures more effectively. After completing the activities, students completed a questionnaire regarding their attitudes and experiences, as well as a knowledge test. The questionnaire revealed that students found the activities motivating, useful, and accessible, highlighting increased engagement, improved conceptual understanding, and a preference for interactive model‑based approaches over traditional lectures. Both groups completed a knowledge test, and the results showed that the experimental group scored significantly higher. Statistical analysis confirmed that these differences were statistically significant. These findings indicate that cooperative IBL using hands‑on molecular models is an effective teaching strategy for improving conceptual understanding, mastery of stereochemical concepts, and the development of higher-order thinking. Moreover, students demonstrated an enhanced ability to apply learned concepts and terminology in new and more complex contexts, indicating a deeper and more lasting understanding of the material.

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Published

2026-06-25

How to Cite

Naumoska, A., Bogdanov, J., & Aleksovska, S. . (2026). Inquiry-based learning in stereochemistry: Strengthening 3D visualization and conceptual understanding. Macedonian Journal of Chemistry and Chemical Engineering, 45(1). https://doi.org/10.20450/mjcce.2026.3443

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Education

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