Antioxidant capacity and antimicrobial effects of zinc complexes of flavonoids – Does synergism exist?

Authors

  • Leposava Pavun Faculty of Pharmacy, University of Belgrade
  • Aleksandra Janošević-Ležaić Faculty of Pharmacy, University of Belgrade
  • Slađana Tanasković Faculty of Pharmacy, University of Belgrade
  • Dušan Ušjak Faculty of Pharmacy, University of Belgrade
  • Marina Milenković Faculty of Pharmacy, University of Belgrade
  • Snezana Uskokovic-Markovic Faculty of Pharmacy, University of Belgrade

DOI:

https://doi.org/10.20450/mjcce.2021.2401

Keywords:

flavonoids, zinc, antioxidants, antimicrobial effect

Abstract

There is a constant need for effective drugs, combinations of drugs and methods for the prevention of bacterial and viral infections, including coronavirus. It is known that the role of trace elements in strengthening the human immune system is significant. Vitamins, trace elements, including zinc, iron, selenium, magnesium and copper, and omega-3 fatty acids, play essential physiological roles in promoting the immune system. Zinc is a necessary microelement for basic enzymatic physiological processes; it plays an important role in cell division and is involved in the development of cells responsible for non-specific immunity. Zinc deficiency is known to predispose patients to viral infection due to reduced antiviral immunity. In addition, flavonoids as plant metabolites play an important role in oxidative stress prevention. This manuscript aims to discuss the roles of zinc, flavonoids and their complexes in vitro, as well as their antioxidant and antimicrobial activities. The justification for the simultaneous use of zinc and flavonoids is also considered.

Author Biographies

Aleksandra Janošević-Ležaić, Faculty of Pharmacy, University of Belgrade

Department of Physical Chemistry and Instrumental Methods

Marina Milenković, Faculty of Pharmacy, University of Belgrade

Department of Microbiology and Immunology

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Published

2021-11-26

How to Cite

Pavun, L., Janošević-Ležaić, A., Tanasković, S., Ušjak, D., Milenković, M., & Uskokovic-Markovic, S. (2021). Antioxidant capacity and antimicrobial effects of zinc complexes of flavonoids – Does synergism exist?. Macedonian Journal of Chemistry and Chemical Engineering, 40(2), 231–239. https://doi.org/10.20450/mjcce.2021.2401

Issue

Vol. 40 No. 2 (2021)

Section

Natural Products

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